RELATIONSHIP OF DIRTY NECROSIS WITH HISTOPATHOLOGICAL GRADING IN COLORECTAL ADENOCARCINOMA

Background: Dirty necrosis (Intraacinar necrosis/garland necrosis) is defined as the presence of cell remnants in lumen gland. consisting an eosinophilic mass, which a mass originating from cytoplasm dead cells mixed with nucleus. The nucleus are blue and pink background. results breakdown carcinoma cells, usually accumulate intact tubular glands, may be associated spontaneous events involving insufficient tumor vascular supply. Assessment dirty considered characteristic colorectal carcinoma. Objective: This study was conducted to analyze relationship between histopathological grading adenocarcinoma. Methods: used 55 paraffin block samples adenocarcinoma cases that had been diagnosed at Anatomical Pathology Laboratory, H. Adam Malik Hospital, Medan Faculty Medicine, Universitas Sumatera Utara, since 2019-2020. assessed using H&E staining 400x magnification over entire gland, if <10% absent >10% present. Results: showed there were 47 (85.4%) necrosis, while 8 (14.6%) did not. For most grading, 42 (73.4%) low grade, high grade 13 (23.6%). Statistical tests no significant p value = 0.376 (p >0.05). Conclusion: There statistically